Linked Life Data

2860677

Source:http://linkedlifedata.com/resource/pubmed/id/2860677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-7-9
pubmed:abstractText
The radiolabeled alpha-1-adrenoceptor antagonist [3H]WB-4101 was used to determine whether supersensitivity of the guinea pig vas deferens that develops after denervation or reserpine pretreatment is associated with a change in the characteristics of the alpha-1-adrenoceptor. Specific binding of [3H]WB-4101 to membrane fractions of vasa deferentia was saturable and reversible. The dissociation constant (KD) was similar when obtained by equilibrium or kinetic studies. As determined by Scatchard analysis, neither chronic (5 days) pretreatment with reserpine (1.0 mg/kg/day) nor postganglionic denervation (7 days) altered the number or affinity of [3H] WB-4101 binding sites. It is concluded that changes in alpha-1-receptor characteristics are not responsible for postjunctional supersensitivity in this tissue.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-7012
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of postganglionic denervation and pretreatment with reserpine on alpha-adrenoceptors of the guinea-pig vas deferens.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.