Linked Life Data

2859558

Source:http://linkedlifedata.com/resource/pubmed/id/2859558

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-6-6
pubmed:abstractText
The involvement of N-methyl-D-aspartate (NMDA) receptors in synaptic transmission in the Schaffer collateral-commissural pathway of rat hippocampal slices has been examined in the presence and absence of Mg2+. Superfusion of slices with Mg2+ -free medium resulted in an increase in the amplitude of the population spike and the appearance of multiple population spikes. An NMDA antagonist, which had no effect on the synaptic response in the presence of Mg2+, completely prevented the appearance of multiple responses. If added to slices already bathed in Mg2+ -free medium, the antagonist eliminated the multiple responses and partly reduced the amplitude of the initial population spike. These data suggest that the extent to which NMDA receptors participate in synaptic transmission in rat hippocampus depends on the extracellular Mg2+ concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Magnesium ions block an N-methyl-D-aspartate receptor-mediated component of synaptic transmission in rat hippocampus.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't