Linked Life Data

2859539

Source:http://linkedlifedata.com/resource/pubmed/id/2859539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-6-6
pubmed:abstractText
Target neurons for 3H-corticosterone were identified by autoradiography and tyrosine hydroxylase containing neurons were identified by immunocytochemistry in the same sections of lower brain stem of 38-day-old rats, 10-day-old rats and adult mice. In all animals studied, the same topographic distribution of neurons was found which exhibited a nuclear accumulation of 3H-corticosterone. Target neurons for 3H-corticosterone were widely distributed in the brain stem. Motor neurons of the cranial nerves and certain neurons of the reticular formation were among the most heavily labeled cells. Neurons containing immunoreactive tyrosine hydroxylase were detected in all of the classical noradrenergic and adrenergic cell groups. Tyrosine hydroxylase containing neurons did not concentrate radioactivity, but were found in close proximity to neurons which concentrated the radiolabeled glucocorticosteroid, especially in the ventrolateral medulla (area A1) and in the ventrolateral pons (area A5). These results do not support, but do not exclude, a direct genomic action of corticosterone on catecholamine neurons in the lower brain stem.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-71
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
A combined autoradiographic and immunocytochemical study of 3H-corticosterone target neurons and catecholamine neurons in rat and mouse lower brain stem.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.