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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-4-26
|
| pubmed:abstractText |
Rectal absorption of insulin by depancreatized dogs was significantly enhanced by the coadministration of enamine as a suppository adjuvant and if this was followed by a further suppository containing enamine alone, the insulin absorption was even further enhanced. The additional enamine suppository resulted in high serum insulin concentrations for a longer time and effected a significant decrease in serum glucose concentrations. To decrease serum glucose concentrations effectively in depancreatized dogs, serum insulin levels had to remain high for a long period of time, rather than be transient.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-3573
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
22-6
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2858523-Adjuvants, Pharmaceutic,
pubmed-meshheading:2858523-Amines,
pubmed-meshheading:2858523-Animals,
pubmed-meshheading:2858523-Biological Availability,
pubmed-meshheading:2858523-Dogs,
pubmed-meshheading:2858523-Insulin,
pubmed-meshheading:2858523-Intestinal Absorption,
pubmed-meshheading:2858523-Pancreatectomy,
pubmed-meshheading:2858523-Rectum,
pubmed-meshheading:2858523-Suppositories
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Enhanced bioavailability of insulin after rectal administration with enamine as adjuvant in depancreatized dogs.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|