Linked Life Data

2858392

Source:http://linkedlifedata.com/resource/pubmed/id/2858392

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-4-26
pubmed:abstractText
Extracts of autopsied human brain tissue exhibited a specific inhibition of [3H]spiroperidol binding, in support of previous reports. The extent of binding inhibition varied depending upon the brain region from which the tissue was taken. We observed two peaks of inhibition binding from extracts of caudate or putamen placed on a Sephadex G10 column. Results of experiments to characterize the extract in the second peak indicate a correlation between inhibition of spiroperidol binding and dopamine content of the tissue. The content of the first peak could not be definitively identified but indirect evidence indicates that it may be a high molecular weight conjugate of dopamine that is formed at low concentrations. No evidence was obtained to suggest the existence of previously undetected neuroleptic-like material in human brain.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Inhibition of neuroleptic binding by human brain extracts--an effect of endogenous dopamine?
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.