Linked Life Data

2857713

Source:http://linkedlifedata.com/resource/pubmed/id/2857713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-4-4
pubmed:databankReference
pubmed:abstractText
The human pro-alpha 1(I) collagen gene is 18 kilobases long, and its coding information is subdivided in 51 exons. We have recently reported a detailed analysis of this elaborate structure. Here we describe the exact termini of the gene as well as its 5' flanking sequences (promoter region). Sequence comparison between the human and mouse pro-alpha 1(I) gene showed an unusual highly conserved region 5' to the initiation site of transcription, which may be important for pro-alpha 1(I) collagen expression. Sequence comparison between the pro-alpha 1(I) and other collagen genes revealed the presence of a conserved secondary structure possibly implicated in the regulation of collagen mRNA translation and/or collagen secretion. Two short repetitive sequences closely associated with the pro-alpha 1(I) gene have been identified to be different members of the AluI family of repeats. Like the independently co-expressed pro-alpha 2(I) collagen gene, the analysis of the last exon has revealed that the pro-alpha 1(I) gene transcribes two different mRNAs in cultured fibroblasts. The colinearity and exact location of the termini of these transcripts, as well as their monogenic nature, have been conclusively determined.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
260
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2315-20
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Fine structural analysis of the human pro-alpha 1 (I) collagen gene. Promoter structure, AluI repeats, and polymorphic transcripts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't