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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-8-31
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pubmed:abstractText |
In order to characterize the pharmacological properties of post-junctional alpha-adrenoceptors, the vasoconstricting effects of the non-specific alpha-adrenoceptor agonist noradrenaline, of the specific alpha 1-adrenoceptor agonist phenylephrine and of the specific alpha 2-adrenoceptor agonist azepexole and the interaction with the calcium entry blockers nifedipine and diltiazem were studied in hand veins of eight healthy volunteers. Both subtypes of alpha-adrenoceptors could be demonstrated in human hand veins in vivo. The alpha 1-subtype seemed to prevail. Vasoconstriction induced by stimulation of either post-synaptic alpha 1- or alpha 2-adrenoceptors was reduced by the calcium entry blockers diltiazem and nifedipine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0952-1178
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S239-41
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pubmed:dateRevised |
2005-6-8
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pubmed:meshHeading |
pubmed-meshheading:2856818-Adult,
pubmed-meshheading:2856818-Calcium Channel Blockers,
pubmed-meshheading:2856818-Diltiazem,
pubmed-meshheading:2856818-Drug Interactions,
pubmed-meshheading:2856818-Hand,
pubmed-meshheading:2856818-Humans,
pubmed-meshheading:2856818-Male,
pubmed-meshheading:2856818-Middle Aged,
pubmed-meshheading:2856818-Nifedipine,
pubmed-meshheading:2856818-Receptors, Adrenergic, alpha,
pubmed-meshheading:2856818-Regional Blood Flow,
pubmed-meshheading:2856818-Vasoconstriction,
pubmed-meshheading:2856818-Veins
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pubmed:year |
1985
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pubmed:articleTitle |
Specific alpha-adrenoceptor-mediated vasoconstriction in human veins and interaction with the calcium entry blockers nifedipine and diltiazem.
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pubmed:affiliation |
Department of Internal Medicine, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article
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