Linked Life Data

2856771

Source:http://linkedlifedata.com/resource/pubmed/id/2856771

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-8-31
pubmed:abstractText
A parenteral preparation of captopril has been used to produce a smooth reduction of blood pressure in patients presenting with accelerated phase hypertension. In five out of six patients studied, an intravenous infusion of captopril at dose rates ranging from 250-2000 micrograms/h lowered blood pressure from 199 +/- 13/115 +/- 5 to 143 +/- 14/86 +/- 5 mmHg over several hours without adverse effects. Partial inhibition of the angiotensin converting enzyme was demonstrated by a rise in plasma renin activity (PRA) and a fall (although not to normal) in elevated levels of angiotensin II and aldosterone. The plasma level of free captopril at the point of blood pressure control was 15 +/- 4 ng/ml and its short effective half-life was demonstrated by a rise in blood pressure within 15 minutes of stopping the infusion. These data demonstrate that very small amounts of captopril can produce a dose-dependent inhibition of angiotensin converting enzyme without abrupt changes in blood pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S475-7
pubmed:dateRevised
2005-6-8
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Inhibition of the renin-angiotensin-aldosterone axis by low dose intravenous captopril as a treatment for accelerated phase hypertension.
pubmed:affiliation
Department of Medicine, Western General Hospital, Edinburgh, Scotland.
pubmed:publicationType
Journal Article