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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1989-8-31
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pubmed:abstractText |
Murine leukemia virus (MuLV) induced T-lymphomas bear surface receptors specific for the leukemogenic retroviruses they produce. We have proposed that such virus receptors on lymphoid tumors are the antigen-specific receptors present on their normal lymphocyte counterparts. To determine the relationship between immune receptors and virus receptors on malignant lymphocytes, a spontaneous B cell lymphoma, BCL1, was investigated. BCL1-lymphoma cells from an in vivo passaged BCL1-cell line grew in vitro only in contact with splenic stromal cells. These stromal cells produced a retrovirus, termed BCL1-V, which was lymphotropic but not leukemogenic. BCL1 cells bound BCL1-V, whereas normal spleen cells did not. Isolated BCL1-IgM bound BCL1-V, whereas three other IgM myeloma proteins, MOPC-104E, CBPC-112, and HPC-76, did not. Rat anti-BCL1-IgM monoclonal antibodies recognizing mu chain isotypic determinants and BCL1-specific idiotypic specificities, blocked BCL1-V binding to BCL1 IgM. These data support the receptor mediated leukemogenesis hypothesis, suggest a role for virus:cell surface immunoglobulin interactions in the development of B cell lymphoma, and implicate an antigen presenting cell population in the lymphomagenic process.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0724-6803
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-42
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2855408-Animals,
pubmed-meshheading:2855408-B-Lymphocytes,
pubmed-meshheading:2855408-Immunoglobulin M,
pubmed-meshheading:2855408-Leukemia Virus, Murine,
pubmed-meshheading:2855408-Lymphoma,
pubmed-meshheading:2855408-Mice,
pubmed-meshheading:2855408-Mice, Inbred BALB C,
pubmed-meshheading:2855408-Receptors, Antigen, B-Cell,
pubmed-meshheading:2855408-Receptors, Virus,
pubmed-meshheading:2855408-Retroviridae,
pubmed-meshheading:2855408-Tumor Cells, Cultured
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pubmed:year |
1987
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pubmed:articleTitle |
Receptor mediated leukemogenesis: murine leukemia virus interacts with BCL1 lymphoma cell surface IgM.
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pubmed:affiliation |
Department of AIDS Activities/Oncology, San Francisco General Hospital/ University of California 94110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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