Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1989-5-16
|
| pubmed:abstractText |
Effects of the nootropic drugs, piracetam and bifemelane, on long-term potentiation (LTP) of population spikes in the CA3 and CA1 regions of guinea pig hippocampal slices were investigated. Piracetam (10(-6) to 10(-4) M) and bifemelane (10(-8) to 10(-6) M) significantly augmented the LTP in the CA3 region. The effects of these drugs were inhibited by scopolamine (10(-6) M). However, the LTP in the CA1 region was not affected by piracetam and bifemelane even at highly effective concentrations (10(-5) and 10(-6) M, respectively). Thus, the LTP in the CA3 is more susceptible to nootropic drugs than in the CA1.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
236-41
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2853846-Animals,
pubmed-meshheading:2853846-Benzhydryl Compounds,
pubmed-meshheading:2853846-Evoked Potentials,
pubmed-meshheading:2853846-Guinea Pigs,
pubmed-meshheading:2853846-Hippocampus,
pubmed-meshheading:2853846-Male,
pubmed-meshheading:2853846-Piracetam,
pubmed-meshheading:2853846-Pyrrolidinones,
pubmed-meshheading:2853846-Synapses,
pubmed-meshheading:2853846-Synaptic Transmission
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Different susceptibilities of long-term potentiations in CA3 and CA1 regions of guinea pig hippocampal slices to nootropic drugs.
|
| pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
|
| pubmed:publicationType |
Journal Article
|