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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-5-16
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pubmed:abstractText |
A radioactive enkephalin affinity reagent, selective for the mu opioid receptor subtype, was synthesized by a fragment condensation method. 3H-BOC-Tyr-D-Ala-Gly-OH was prepared by catalytic tritiation of the protected iodinated tripeptide. The protected tritiated tripeptide and N(Me)Phe-CH2Cl were condensed by the mixed anhydride method. The protecting group was removed by HCl/acetic acid. The tritiated tetrapeptide has a specific radioactivity of 56.8 Ci/mmole (2.1 TBq/mmole).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0143-4179
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2853836-Affinity Labels,
pubmed-meshheading:2853836-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:2853836-Animals,
pubmed-meshheading:2853836-Binding, Competitive,
pubmed-meshheading:2853836-Brain,
pubmed-meshheading:2853836-Cell Membrane,
pubmed-meshheading:2853836-Indicators and Reagents,
pubmed-meshheading:2853836-Isotope Labeling,
pubmed-meshheading:2853836-Kinetics,
pubmed-meshheading:2853836-Rats,
pubmed-meshheading:2853836-Receptors, Opioid,
pubmed-meshheading:2853836-Receptors, Opioid, mu,
pubmed-meshheading:2853836-Tritium
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pubmed:year |
1988
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pubmed:articleTitle |
Synthesis of 3H-Tyr-D-Ala-Gly-N(Me)Phe chloromethyl ketone--an opioid affinity label.
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pubmed:affiliation |
Institute of Biochemistry, Hungarian Academy of Sciences, Szeged.
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pubmed:publicationType |
Journal Article
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