Linked Life Data

2852916

Source:http://linkedlifedata.com/resource/pubmed/id/2852916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1989-4-19
pubmed:abstractText
The effect of newly synthesized halogenated isoflavans and isoflavenes on human rhinovirus 1B (HRV 1B) infection of HeLa cells has been examined. Both series of drugs inhibited virus plaque formation in cell cultures, isoflavans being more effective than isoflavenes. Cells pretreated with compounds before challenge with HRV 1B became resistant to the virus-induced cytopathic effect. The antiviral state induced by the most active compounds persisted for at least 10 h and did not appear to be mediated by interferon production. Experiments whereby the compounds were added at varying times indicated that the isoflavans and isoflavenes interfere with early events of virus replication without affecting virus binding to the cell membrane. In addition to their effects on virus multiplication, the isoflavans were also found to have a direct action on the virus. The inhibitory effect on virus infectivity required extraction with chloroform for reversal. Isoflavans also protected the virions against mild acid or heat inactivation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0166-3542
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-27
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effect of isoflavans and isoflavenes on rhinovirus 1B and its replication in HeLa cells.
pubmed:affiliation
Institute of Microbiology, University of Rome, La Sapienza, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't