Linked Life Data

2852442

Source:http://linkedlifedata.com/resource/pubmed/id/2852442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-3-27
pubmed:abstractText
This study was performed on 12 anaesthetized pigs in order to examine the effect of the 'loop' diuretic bumetanide (inhibitor of Na,K,Cl-co-transport) on ductular bile secretion. It has previously been shown that administration of furosemide (a less potent 'loop' diuretic) to dogs and rats increases bile flow due to inhibition of ductular reabsorption of electrolytes and water. In group I (n = 6) bumetanide (median biliary concentration: 8.4 x 10(-3) mol l-1) increased bile flow and biliary concentration of HCO3 by 200% (116-320) and 50% (26-96), respectively. Biliary concentration of Cl was significantly decreased by 6% (2-12) following administration of bumetanide. In group II (n = 6) bile secretion was measured during secretin infusion (3 CU kg b. wt h-1) in the arterial pH range of 7.40-7.00, both before and after bumetanide administration in each animal. Bumetanide (median biliary concentration: 2.7 x 10(-3) mol I-1) did not significantly alter biliary secretion of water, HCO3, Na, K or Cl. Bile acid secretion was reduced by 30% from 43 (28-55) to 30 (17-41) mumol min-1 (P less than 0.05) while hepatic venous concentration of bile acids was raised by 90% (54-126) from 184 (113-309) to 350 (229-502) mumol l-1 (P less than 0.05) at slightly increased hepatic blood flow. Hepatic venous serum concentration of bumetanide was 4.8 (2.1-7.4) x 10(-4) mol l-1 (unbound fraction).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of bumetanide on bile flow in the pig.
pubmed:affiliation
University of Oslo, Institute for Experimental Medical Research, Norway.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't