Linked Life Data

2851570

Source:http://linkedlifedata.com/resource/pubmed/id/2851570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1989-3-22
pubmed:abstractText
For each of 3 separate evaluations, 6 fasted llamas (Lama glama) were sedated with xylazine (1.1 mg/kg of body weight, IV) and then 15 minutes later were given normal saline solution (5.0 ml, IV; control values), doxapram (2.2 mg/kg, IV), or 4-amino-pyridine (0.3 mg/kg, IV) and yohimbine (0.125 mg/kg, IV). After administration of 4-aminopyridine and yohimbine, the llamas stood in a mean of 11 minutes and resumed eating in a mean of 34 minutes; both means were significantly less (P less than 0.05) than control values (46 minutes and 67 minutes, respectively). Doxapram induced muscle fasciculations, and (compared with control values) did not significantly decrease the time to standing (41 minutes) or the time until the animals resumed eating (68 minutes). Yohimbine and 4-aminopyridine in combination rapidly antagonized xylazine-induced sedation in llamas, whereas doxapram was ineffective as an antagonist of xylazine-induced sedation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-1488
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
189
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1059-61
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Reversal of xylazine-induced sedation in llamas, using doxapram or 4-aminopyridine and yohimbine.
pubmed:affiliation
Veterinary Teaching Hospital, College of Veterinary Medicine, Oregon State University, Corvallis 97331.
pubmed:publicationType
Journal Article