rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
5
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pubmed:dateCreated |
1989-3-21
|
pubmed:abstractText |
A series of chlorophenoxyalkyl acids were prepared and evaluated as pharmacological antagonists of leukotriene D4. Structure-activity relationship studies pointed to LY137617 as a compound with possible therapeutic value. In experiments on isolated smooth muscles from the guinea-pig, this agent was a selective and moderately potent antagonist of leukotriene D4 and also leukotriene E4. Other in vitro experiments demonstrated that LY137617 had a high affinity for protein molecules. This was reflected in vivo as a weaker than expected efficacy against leukotriene-mediated events, limiting the compound's potential as a clinical candidate. Nevertheless, agents of this type will prove useful in the laboratory to increase knowledge of leukotriene receptor-antagonist interactions.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Azoles,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene E4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/SRS-A,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles
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pubmed:status |
MEDLINE
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pubmed:issn |
0378-6501
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
303-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2851426-Animals,
pubmed-meshheading:2851426-Azoles,
pubmed-meshheading:2851426-Guinea Pigs,
pubmed-meshheading:2851426-Ileum,
pubmed-meshheading:2851426-Leukotriene B4,
pubmed-meshheading:2851426-Leukotriene E4,
pubmed-meshheading:2851426-Lung,
pubmed-meshheading:2851426-Male,
pubmed-meshheading:2851426-Muscle, Smooth,
pubmed-meshheading:2851426-Muscle Contraction,
pubmed-meshheading:2851426-Receptors, Immunologic,
pubmed-meshheading:2851426-Receptors, Leukotriene,
pubmed-meshheading:2851426-Receptors, Leukotriene B4,
pubmed-meshheading:2851426-SRS-A,
pubmed-meshheading:2851426-Structure-Activity Relationship,
pubmed-meshheading:2851426-Tetrazoles,
pubmed-meshheading:2851426-Trachea
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pubmed:year |
1988
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pubmed:articleTitle |
Leukotriene receptor antagonists. III. Pharmacological and chemical studies with LY137617, a leukotriene D4 and leukotriene E4 receptor antagonist.
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pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.
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pubmed:publicationType |
Journal Article,
In Vitro
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