|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1989-3-17
|
|
pubmed:abstractText |
1. The effects of chronic dietary supplementation with omega 3 polyunsaturated fatty acids on endothelium-dependent relaxations were examined in isolated coronary microvessels of the pig. 2. Animals were maintained for four weeks with or without dietary supplementation of purified eicosapentaenoic acid (3.5 g daily) and docosahexaenoic acid (1.5 g daily). Fatty acid profiles of plasma lipids showed that only the fraction of eicosapentaenoic acid increased by the treatment, together with a decrease of that of arachidonic acid. 3. In the treated group, endothelium-dependent relaxations to bradykinin were significantly augmented, while contractions to acetylcholine or relaxations to nitroprusside were unaltered. 4. These results indicate that dietary omega 3 polyunsaturated fatty acids (mainly eicosapentaenoic acid) augment endothelium-dependent relaxations in coronary microvessels of the pig, without changing the ability of vascular smooth muscle to contract or relax.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-14206987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-2871807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-3000343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-3106833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-3115623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-3498901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-3719611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-39089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-6099719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-6268128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-6297832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-6313250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-6933458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2851360-862138
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
95
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1191-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2851360-Animals,
pubmed-meshheading:2851360-Bradykinin,
pubmed-meshheading:2851360-Coronary Vessels,
pubmed-meshheading:2851360-Dietary Fats, Unsaturated,
pubmed-meshheading:2851360-Docosahexaenoic Acids,
pubmed-meshheading:2851360-Eicosapentaenoic Acid,
pubmed-meshheading:2851360-Male,
pubmed-meshheading:2851360-Microcirculation,
pubmed-meshheading:2851360-Muscle, Smooth, Vascular,
pubmed-meshheading:2851360-Muscle Contraction,
pubmed-meshheading:2851360-Muscle Relaxation,
pubmed-meshheading:2851360-Swine
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Dietary omega 3 polyunsaturated fatty acids augment endothelium-dependent relaxation to bradykinin in coronary microvessels of the pig.
|
|
pubmed:affiliation |
Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
