|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0018546,
umls-concept:C0060264,
umls-concept:C0073721,
umls-concept:C0178784,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0636068,
umls-concept:C1167624,
umls-concept:C1548779,
umls-concept:C1704711,
umls-concept:C1883254,
umls-concept:C1947902,
umls-concept:C2827499
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1989-3-9
|
|
pubmed:abstractText |
Ferrocene-Haloperidol was synthesized by N-alkylation of 4-(4'-chlorophenyl)- 4-hydroxypiperidine with 1-ferrocenyl-4-chlor-butan-1-on. By heating the ferrocene-haloperidol with 103RuCl3 the 103Ru-labelled ruthenocene-haloperidol was obtained. This compound showed a high affinity for lung but not for brain in rats and mice. The decay of the 103Ru labelled compound results in the formation of the 103mRh labelled rhodocene-haloperidol, which is rapidly oxidized by air to the corresponding rhodocinium-haloperidol. This compound can be separated by extraction and TLC.
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|
pubmed:language |
ger
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0883-2889
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
39
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1237-41
|
|
pubmed:dateRevised |
2009-6-4
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
[Ferrocene, ruthenocene and rhodocene analogs in haloperidol synthesis and organ distribution after labeling with 103Ru and 103mRh].
|
|
pubmed:affiliation |
Pharmazeutisches Institut, Freie Universität Berlin, Berlin-Dahlem, Deutschland.
|
|
pubmed:publicationType |
Journal Article,
English Abstract
|
