| pubmed-article:2850261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C0018422 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C0600401 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:2850261 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:2850261 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2850261 | pubmed:dateCreated | 1989-2-23 | lld:pubmed |
| pubmed-article:2850261 | pubmed:abstractText | Mutations at the suppressor of Hairy-wing [su(Hw), 3-54.8] locus reverse the phenotype of second-site mutations induced by the gypsy transposable element in Drosophila melanogaster. This gene encodes a protein with a predicted molecular weight of 109,000 that contains an acidic domain and 12 copies of the DNA-binding 'Zn finger' motif. The su(Hw) protein was overexpressed in Escherichia coli and Drosophila cells, and partially purified. It was shown to interact specifically in vitro with a 367-bp DNA fragment that contains 12 copies of the sequence PyPuTTGCATACCPy located in the 5'-untranslated region of gypsy, between the 5' long terminal repeat (LTR) and the first ATG initiation codon. This sequence shows striking homology to some mammalian transcriptional enhancer elements, supporting a role for the su(Hw) protein in the control of gypsy transcription. In addition, the su(Hw) protein is present at approximately 100-200 sites on Drosophila polytene chromosomes, suggesting that it also interacts in vivo with DNA and might be involved functionally in the regulation of normal cellular genes. | lld:pubmed |
| pubmed-article:2850261 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2850261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2850261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2850261 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2850261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2850261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2850261 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2850261 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2850261 | pubmed:author | pubmed-author:CorcesV GVG | lld:pubmed |
| pubmed-article:2850261 | pubmed:author | pubmed-author:HarrisonD ADA | lld:pubmed |
| pubmed-article:2850261 | pubmed:author | pubmed-author:SpanaCC | lld:pubmed |
| pubmed-article:2850261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2850261 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2850261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2850261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2850261 | pubmed:pagination | 1414-23 | lld:pubmed |
| pubmed-article:2850261 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2850261 | pubmed:meshHeading | pubmed-meshheading:2850261-... | lld:pubmed |
| pubmed-article:2850261 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2850261 | pubmed:articleTitle | The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon. | lld:pubmed |
| pubmed-article:2850261 | pubmed:affiliation | Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218. | lld:pubmed |
| pubmed-article:2850261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2850261 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2850261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:41740 | entrezgene:pubmed | pubmed-article:2850261 | lld:entrezgene |
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