|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1989-2-9
|
|
pubmed:abstractText |
In previously frozen and extensively washed brain membranes [3H]glutamate binds to a single population of sites characteristic of the NMDA-sensitive glutamate receptor subtype. This binding cannot be displaced by glycine and D-serine, but actually is enhanced by these amino acids in a dose-dependent manner. Glycine and D-serine increase the affinity of glutamate binding without changing the density of binding sites. These results delineate glycine as an allosteric modulator of the recognition site for the NMDA-sensitive glutamate receptor.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0028-3908
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1183-5
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:2849731-Animals,
pubmed-meshheading:2849731-Aspartic Acid,
pubmed-meshheading:2849731-Brain,
pubmed-meshheading:2849731-Glutamates,
pubmed-meshheading:2849731-Glycine,
pubmed-meshheading:2849731-Male,
pubmed-meshheading:2849731-N-Methylaspartate,
pubmed-meshheading:2849731-Rats,
pubmed-meshheading:2849731-Rats, Inbred Strains,
pubmed-meshheading:2849731-Receptors, Glutamate,
pubmed-meshheading:2849731-Receptors, Neurotransmitter,
pubmed-meshheading:2849731-Serine,
pubmed-meshheading:2849731-Synaptic Membranes
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.
|
|
pubmed:affiliation |
Fidia-Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, Washington, D.C. 20007.
|
|
pubmed:publicationType |
Journal Article
|
