Linked Life Data

2848774

Source:http://linkedlifedata.com/resource/pubmed/id/2848774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-1-25
pubmed:abstractText
Malondialdehyde (MDA) is a product of free-radical reaction with lipids and has been implicated in a variety of pathological processes including inflammation and carcinogenesis. In order to document the toxic reactions related to the pathogenic mechanisms of mineral fibers, asbestos and other mineral dusts were examined for their potency to produce lipid peroxidation using the thiobarbital method for MDA measurement. Human peripheral blood-derived neutrophils (PMN), guinea pig peritoneal macrophages, and guinea pig alveolar lavage cells produced MDA when treated with crocidolite asbestos. Of the various mineral dusts tested, only crocidolite showed a significant increase of MDA production. The amount of MDA produced by PMN treated with crocidolite increased with milling the fiber and with the incubation time. Both superoxide dismutase (SOD) and catalase were examined for their ability to inhibit MDA formation. At concentrations of up to 50 micrograms/10(6) cells, SOD did not inhibit the MDA formation in macrophages. However, catalase at the same concentration inhibited MDA formation in macrophages completely. A possible mechanism of MDA formation and its relationship with superoxide production are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-0131
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Mineral fiber-induced malondialdehyde formation and effects of oxidant scavengers in phagocytic cells.
pubmed:affiliation
Department of Public Health, Teikyo University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't