Linked Life Data

2848049

Source:http://linkedlifedata.com/resource/pubmed/id/2848049

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
1989-1-11
pubmed:abstractText
Studies were conducted to explore the effects of pentagastrin, cimetidine, cimetidine with pentagastrin and atropine with pentagastrin, on the gastric acidity and on cAMP accumulation in gastric fundic mucosa in six healthy human beings. Following gastroscopy, gastric juice was collected, and total gastric acidity was measured. Biopsies of fundic mucosa were obtained for estimation of cAMP. All these measurements were taken place before (control) and after the administration of the medicaments. Pentagastrin increased total gastric acidity and cAMP accumulation. Cimetidine decreased both respectively. Combination of cimetidine with pentagastrin and atropine with pentagastrin increased total gastric acidity and cAMP concentration of gastric mucosa. An excellent linear correlation was also found between gastric acidity and fundic mucosal cAMP. These results support the hypothesis of a regulatory role for pentagastrin and cimetidine in total gastric acidity via a cAMP dependent mechanism in gastric mucosa in human. Our findings give a strong indication in Grossman's proposal that the parietal cell has multiple receptors sites.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-7697
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
484-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Role of cyclic AMP in gastric secretion. Mechanism of action of pentagastrin and cimetidine].
pubmed:affiliation
Service de Chirurgie Générale, Hôpital Sismanoglion, Athènes, Grèce.
pubmed:publicationType
Journal Article, English Abstract