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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-12-20
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pubmed:abstractText |
The effect of ACTH on glycolysis has been studied in Y-1 tumor adrenal cells. ACTH caused a sustained increase in the liberation of lactate as well as a stimulation of both basal and glucose-induced fructose 2,6-bisphosphate content. ACTH produces changes also in the activities of phosphofructokinase-1 and phosphofructokinase-2. The addition of Ca2+ or dibutyryl cyclic AMP did not modify neither lactate production nor fructose 2,6-bisphosphate levels. The results suggest that fructose 2,6-bisphosphate regulates ACTH-induced glycolysis at the phosphofructokinase-1 step, although the biochemical mechanism of phosphofructokinase-2 activation remains elusive.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0158-5231
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-76
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2847736-Adrenal Gland Neoplasms,
pubmed-meshheading:2847736-Adrenocorticotropic Hormone,
pubmed-meshheading:2847736-Animals,
pubmed-meshheading:2847736-Bucladesine,
pubmed-meshheading:2847736-Calcium,
pubmed-meshheading:2847736-Fructosediphosphates,
pubmed-meshheading:2847736-Glucose,
pubmed-meshheading:2847736-Glycolysis,
pubmed-meshheading:2847736-Hexosediphosphates,
pubmed-meshheading:2847736-Lactates,
pubmed-meshheading:2847736-Phosphofructokinase-1,
pubmed-meshheading:2847736-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
ACTH stimulates fructose 2,6-bisphosphate synthesis and glycolysis in Y-1 adrenal tumor cells.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Medicine, University of Sevilla, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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