Linked Life Data

2847715

Source:http://linkedlifedata.com/resource/pubmed/id/2847715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-12-1
pubmed:databankReference
pubmed:abstractText
Endonexin is a 32kDa, calcium-dependent membrane-binding protein that is one of a group of proteins that binds to chromaffin granule membranes and may regulate membrane fusion events occurring during exocytosis. In this study an oligonucleotide probe that codes for a highly conserved, repeated sequence present in this and related proteins was used to isolate a 2,048 nucleotide cDNA encoding endonexin from a bovine liver cDNA library. The translated amino acid sequence of endonexin shows the four domain structure characteristic of proteins in this class. The nucleotide sequence is 55 to 61% identical to that of the related membrane-binding proteins lipocortin, calpactin, endonexin II and (half of) 68kDa calelectrin. Southern blot analysis of bovine genomic DNA suggests the presence of a single gene for this protein. A consensus nucleotide sequence (TCTGGGAACTTC) was identified in the 5' nontranslated portion of the endonexin mRNA that is also represented in the messages for calpactin and endonexin II.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
660-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Cloning and characterization of a cDNA encoding bovine endonexin (chromobindin 4).
pubmed:affiliation
Department of Pharmacology, University of Virginia, Charlottesville 22908.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't