Linked Life Data

2847501

Source:http://linkedlifedata.com/resource/pubmed/id/2847501

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-12-15
pubmed:abstractText
Bovine leukemia virus is the etiological agent of a chronic lymphatic leukemia/lymphoma in cows, sheep, and goats. Infection without neoplastic transformation also was obtained in pigs, rhesus monkeys, chimpanzees, and rabbits, and was observed in capybaras and water buffaloes. Structurally and functionally, BLV is a relative of the human T lymphotropic viruses (HTLV-I and HTLV-II). HTLV-I induces in humans a T cell leukemia, and its type II counterpart has been found in dermatopathic lymphadenopathy, hairy T cell leukemia and prolymphocytic leukemia cases. At variance with HTLV-I, BLV has not been associated with neurological diseases of the degenerative type. BLV, HTLV-I, and HTLV-II show clearcut sequence homologies. The pathology of the BLV-induced disease, most notably, the absence of chronic viremia, a long latency period, and a lack of preferred proviral integration sites in tumors, is similar to that of adult T cell leukemia/lymphoma induced by HTLV-I. The most striking feature of the three naturally transmitted leukemia viruses is the X region located between the env gene and the LTR sequence. The X region contains several overlapping long open reading frames. One of them designated XBL-I encodes a trans-activator function capable of increasing the level of gene expression directed by BLV-LTR and most probably involved in "genetic instability" of BLV-infected cells of the B cell lineage. The genetic instability puts the cell into a context of fragility and ready to move along a number of stages towards full malignancy. Little is known about these events and their causes; we have presented some theoretical possibilities. BLV infection has a worldwide distribution. In temperate climates the virus spreads mostly via iatrogenic transfer of infected lymphocytes. In warm climates and in areas heavily populated by hematophageous insects, there are indications of insect-born propagation of the virus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-3519
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Bovine leukemia: facts and hypotheses derived from the study of an infectious cancer.
pubmed:affiliation
Faculty of Agronomy, Gembloux, Belgium.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't