pubmed-article:2847163 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C0035366 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C1257751 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C0014822 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:2847163 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:2847163 | pubmed:issue | 22 | lld:pubmed |
pubmed-article:2847163 | pubmed:dateCreated | 1988-12-22 | lld:pubmed |
pubmed-article:2847163 | pubmed:abstractText | In vitro infection of murine fetal liver cells with a retrovirus containing v-raf and v-myc oncogenes has produced continuous lines of immature erythroid cells that are leukemogenic. These cells synthesized a factor that stimulated their growth in vitro before autonomous variants emerged. Approximately 1000 high-affinity erythropoietin receptors could be detected per cell, and the hormone induced terminal differentiation in these cells. The lines were generated at an extremely low frequency (approximately 1 in 10(7) cells), suggesting that the combination of raf and myc is insufficient to develop erythroid cell lines and that additional events are necessary for transformation. | lld:pubmed |
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pubmed-article:2847163 | pubmed:language | eng | lld:pubmed |
pubmed-article:2847163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2847163 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:2847163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:2847163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2847163 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2847163 | pubmed:month | Nov | lld:pubmed |
pubmed-article:2847163 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:2847163 | pubmed:author | pubmed-author:NicolaN ANA | lld:pubmed |
pubmed-article:2847163 | pubmed:author | pubmed-author:JohnsonG RGR | lld:pubmed |
pubmed-article:2847163 | pubmed:author | pubmed-author:KlinkenS PSP | lld:pubmed |
pubmed-article:2847163 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2847163 | pubmed:volume | 85 | lld:pubmed |
pubmed-article:2847163 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2847163 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2847163 | pubmed:pagination | 8506-10 | lld:pubmed |
pubmed-article:2847163 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:2847163 | pubmed:year | 1988 | lld:pubmed |
pubmed-article:2847163 | pubmed:articleTitle | In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin. | lld:pubmed |
pubmed-article:2847163 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
pubmed-article:2847163 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2847163 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:2847163 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |