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pubmed-article:2847163pubmed:abstractTextIn vitro infection of murine fetal liver cells with a retrovirus containing v-raf and v-myc oncogenes has produced continuous lines of immature erythroid cells that are leukemogenic. These cells synthesized a factor that stimulated their growth in vitro before autonomous variants emerged. Approximately 1000 high-affinity erythropoietin receptors could be detected per cell, and the hormone induced terminal differentiation in these cells. The lines were generated at an extremely low frequency (approximately 1 in 10(7) cells), suggesting that the combination of raf and myc is insufficient to develop erythroid cell lines and that additional events are necessary for transformation.lld:pubmed
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pubmed-article:2847163pubmed:authorpubmed-author:NicolaN ANAlld:pubmed
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pubmed-article:2847163pubmed:articleTitleIn vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.lld:pubmed
pubmed-article:2847163pubmed:affiliationWalter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.lld:pubmed
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pubmed-article:2847163pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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