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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1988-12-22
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pubmed:abstractText |
In vitro infection of murine fetal liver cells with a retrovirus containing v-raf and v-myc oncogenes has produced continuous lines of immature erythroid cells that are leukemogenic. These cells synthesized a factor that stimulated their growth in vitro before autonomous variants emerged. Approximately 1000 high-affinity erythropoietin receptors could be detected per cell, and the hormone induced terminal differentiation in these cells. The lines were generated at an extremely low frequency (approximately 1 in 10(7) cells), suggesting that the combination of raf and myc is insufficient to develop erythroid cell lines and that additional events are necessary for transformation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-14582157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-168500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-269439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-2822405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-2952651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3002634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3014001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3032891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3032937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3035570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3037944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3090054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3455879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3458027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3467981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3496392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3528861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3529085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-354501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-381791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3875798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-3906410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-4009794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-4525458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6264461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6302322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6304522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6308607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6356357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6548307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6574510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6578507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6678608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6855615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6882371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6937266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6940184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-6943562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-723932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847163-7308288
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8506-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2847163-Abelson murine leukemia virus,
pubmed-meshheading:2847163-Animals,
pubmed-meshheading:2847163-Antigens, Surface,
pubmed-meshheading:2847163-Cell Differentiation,
pubmed-meshheading:2847163-Cell Line,
pubmed-meshheading:2847163-Cell Transformation, Neoplastic,
pubmed-meshheading:2847163-Cells, Cultured,
pubmed-meshheading:2847163-Erythropoietin,
pubmed-meshheading:2847163-Hematopoietic Stem Cells,
pubmed-meshheading:2847163-Leukemia Virus, Murine,
pubmed-meshheading:2847163-Mice,
pubmed-meshheading:2847163-Mice, Inbred CBA,
pubmed-meshheading:2847163-Mice, Inbred Strains,
pubmed-meshheading:2847163-Moloney murine sarcoma virus,
pubmed-meshheading:2847163-Nucleic Acid Hybridization,
pubmed-meshheading:2847163-Oncogenes,
pubmed-meshheading:2847163-Receptors, Cell Surface,
pubmed-meshheading:2847163-Receptors, Erythropoietin,
pubmed-meshheading:2847163-Sarcoma Viruses, Murine
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pubmed:year |
1988
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pubmed:articleTitle |
In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.
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pubmed:affiliation |
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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