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rdf:type |
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lifeskim:mentions |
umls-concept:C0008653,
umls-concept:C0012854,
umls-concept:C0013935,
umls-concept:C0016030,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0426857,
umls-concept:C0449721,
umls-concept:C1442161,
umls-concept:C1515979,
umls-concept:C1622968
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pubmed:issue |
12
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pubmed:dateCreated |
1988-12-20
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pubmed:abstractText |
Human embryonic fibroblasts with a large deletion (11p11.11p15.1) in the short arm of one chromosome 11 (del-11 cells) appeared to be susceptible to transformation by early human papillomavirus type 16 (HPV-16) DNA, whereas diploid human embryonic fibroblasts were not. This difference in susceptibility might be explained by the absence of a tumor suppressor gene located within the deleted part on the short arm of chromosome 11. The presence of abundant viral early-gene transcripts in transformed cells suggests that transformation was induced by an elevated level of an HPV-16 early-gene product(s). The low transcriptional activity of HPV-16 in diploid cells may indicate that cellular genes affect viral transcription. Interruption of the HPV-16 E2 early open reading frame is probably required for high-level HPV-16 early-gene expression driven from the homologous enhancer-promoter region.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-14187925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2434663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2822969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2825033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2826818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2828029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2828035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2828520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2838778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2869285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2877730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2881780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2983228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2987521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2990099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2990217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2990724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-2991933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3009901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3011638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3014503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3020404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3029430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3029771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3031816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3032185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3033289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3036366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3037119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3317834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3463446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-3541204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-6139707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-6171342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-6304740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-648944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-6498787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-7071022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846869-7151039
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4538-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2846869-Blotting, Southern,
pubmed-meshheading:2846869-Cell Division,
pubmed-meshheading:2846869-Cell Transformation, Viral,
pubmed-meshheading:2846869-Cells, Cultured,
pubmed-meshheading:2846869-Chromosome Deletion,
pubmed-meshheading:2846869-Chromosomes, Human, Pair 11,
pubmed-meshheading:2846869-DNA, Viral,
pubmed-meshheading:2846869-Diploidy,
pubmed-meshheading:2846869-Fibroblasts,
pubmed-meshheading:2846869-Humans,
pubmed-meshheading:2846869-Papillomaviridae,
pubmed-meshheading:2846869-RNA, Viral,
pubmed-meshheading:2846869-Transcription, Genetic,
pubmed-meshheading:2846869-Transfection
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pubmed:year |
1988
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pubmed:articleTitle |
Induction of anchorage-independent growth of human embryonic fibroblasts with a deletion in the short arm of chromosome 11 by human papillomavirus type 16 DNA.
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pubmed:affiliation |
Department of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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