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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1988-12-22
|
| pubmed:abstractText |
A-strain influenza virus A/JAP (H2N2) was tested for its ability to induce cytotoxic T cells (Tc) after being rendered non-infectious by either UV or gamma irradiation. Gamma-irradiated virus proved to be more efficient than UV-inactivated virus in priming for a memory Tc cell response or in boosting memory spleen cells in vitro. Most importantly, gamma-inactivated, but not UV-inactivated, A/JAP immunized animals survived lethal challenge with heterologous (A/PC(H3N2), A/WSN(H1N1)) virus as effectively as mice primed with infectious virus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0818-9641
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66 ( Pt 2)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
153-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2846435-Animals,
pubmed-meshheading:2846435-Cross Reactions,
pubmed-meshheading:2846435-Female,
pubmed-meshheading:2846435-Gamma Rays,
pubmed-meshheading:2846435-Immunity,
pubmed-meshheading:2846435-Influenza A virus,
pubmed-meshheading:2846435-Male,
pubmed-meshheading:2846435-Mice,
pubmed-meshheading:2846435-Mice, Inbred BALB C,
pubmed-meshheading:2846435-Orthomyxoviridae Infections,
pubmed-meshheading:2846435-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A viruses.
|
| pubmed:affiliation |
Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra.
|
| pubmed:publicationType |
Journal Article
|