Linked Life Data

2846403

Source:http://linkedlifedata.com/resource/pubmed/id/2846403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-12-20
pubmed:abstractText
Both experimental colitis and human inflammatory bowel disease are characterized by an increased colonic blood flow. The objective of this study was to define the role of neutrophils in the colonic hyperemia associated with acetic acid-induced colitis in rats. One, two, and five days after the acetic acid enema, the colon was separated into five segments. Regional blood flow to each segment was measured using the radioactive microsphere technique. Tissue-associated myeloperoxidase activity was used as an index of neutrophil infiltration. Rectal blood flow and myeloperoxidase activity increased progressively after the acetic acid enema. At 5 days there were 3.9- and 4.6-fold increases in myeloperoxidase activity and blood flow, respectively. Comparable changes were noted in all bowel segments. The results suggest a temporal relationship between colonic blood flow and the extent of neutrophil infiltration. To assess directly the role of circulating and infiltrated neutrophils as mediators of the colitis-induced hyperemia, animals were rendered neutropenic approximately 8 h before the enema and neutropenia was maintained for another 24 h. Neutropenia did not modify the colitis-induced intestinal hyperemia normally observed at 24 h. We conclude from these findings that vasoactive agents derived from neutrophils do not mediate the increased colonic blood flow in this model of ulcerative colitis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1528-34
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Inflammation-induced intestinal hyperemia in the rat: role of neutrophils.
pubmed:affiliation
Department of Physiology, Louisiana State University Medical Center, Shreveport.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.