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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1988-12-21
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pubmed:abstractText |
The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3' of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX ('inhibitors') have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG-rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-2423876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-265567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-2828023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-2834694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-2877398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-2992643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3001143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3032067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3038515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3157994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3524819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3657959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-3941898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-4045960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-4202843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-561093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6092933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6142993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6266915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6269067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6275362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6295880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6315951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6329734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-6843667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2846283-719759
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2795-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2846283-Blotting, Southern,
pubmed-meshheading:2846283-Chromosome Deletion,
pubmed-meshheading:2846283-Cloning, Molecular,
pubmed-meshheading:2846283-DNA,
pubmed-meshheading:2846283-DNA Probes,
pubmed-meshheading:2846283-DNA Restriction Enzymes,
pubmed-meshheading:2846283-Factor IX,
pubmed-meshheading:2846283-Hemophilia B,
pubmed-meshheading:2846283-Humans,
pubmed-meshheading:2846283-Nucleic Acid Hybridization,
pubmed-meshheading:2846283-Oncogenes,
pubmed-meshheading:2846283-Restriction Mapping
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pubmed:year |
1988
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pubmed:articleTitle |
Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients.
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pubmed:affiliation |
Sir William Dunn School of Pathology, University of Oxford, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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