Linked Life Data

2846174

Source:http://linkedlifedata.com/resource/pubmed/id/2846174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-6
pubmed:dateCreated
1988-12-16
pubmed:abstractText
It has been repeatedly reported that several functions of mononuclear cells are impaired in patients affected by neoplasia. Moreover, inhibitory activity of serum and tumor extracts on macrophages have been described. In a previous study, we found a marked impairment of the intrinsic antiviral activity of macrophages derived from monocytes isolated from peripheral blood of patients with breast carcinoma or melanoma compared with that from blood of normal subjects. The aim of the present work was to study whether this impairment was due to circulating inhibitory factors. Macrophages were differentiated in vitro in sera from patients with neoplasia and in sera from healthy donors and then challenged with herpes simplex virus type 2 (HSV-2). Macrophages from normal subjects, incubated with sera from patients, were significantly impaired in their intrinsic antiviral activity. These results support the possibility that circulating inhibitory factors influence the functionality of mononuclear phagocytes in the tumor-bearing host.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0361-090X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Influence of sera from patients affected by neoplasia on some human macrophage functions.
pubmed:affiliation
Institute of Medical Microbiology, Messina University Medical School, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't