Linked Life Data

2845870

Source:http://linkedlifedata.com/resource/pubmed/id/2845870

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-11-3
pubmed:abstractText
This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in guinea pigs, the hydrolysis of epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), and the rapid formation of inositol triphosphate (InsP3). Our data revealed that the incorporation of free [3H]-inositol into phosphatidylinositol 4P and PtdIns4,5P2 of microsomal preparations from hyperproliferative epidermis was markedly elevated when compared with epidermis from normal-fed animals. The reversal of the hyperproliferating epidermis by dietary cross-over supplementations with safflower oil and primrose oil resulted in striking morphological normalization, cellular decrease in epidermal DNA synthesis, decrease in the biosynthesis of 14C-PtdIn4,5P2 from precursor 14C-inositol, and a significant increase in the rapid generation of transient InsP3 by epidermis from the cross-over-fed animals. These findings taken together indicate that the reversal of epidermal hyperproliferation to normal in guinea pig skin and the increased capability of the tissue microsomal preparation to generate InsP3 are linked in this tissue, and raise the possibility that epidermal inositol-phospholipid metabolism may play a role in the pathogenesis of cutaneous hyperproliferative disorders.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-3696
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
286-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Reversal of epidermal hyperproliferation in essential fatty acid deficient guinea pigs is accompanied by rapid generation of inositol triphosphate.
pubmed:affiliation
Department of Dermatology, School of Medicine, University of California, Davis 95616.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.