Linked Life Data

2845856

Source:http://linkedlifedata.com/resource/pubmed/id/2845856

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5A
pubmed:dateCreated
1988-11-16
pubmed:abstractText
Hyperplastic alveolar nodule, present in the young adult non-lactating but mammary tumor virus harbouring mice (RIII), are biologically active precursor lesions which form mammary tumors at certain age. Using mammary explant cultures from these mice as a model for preneoplastic hyperplasia, we have examined the effects of various fatty acids on the changes in the cellular and molecular markers in vitro. We find that exposure of cultures to omega-6 fatty acids results in -13 fold increase on RT activity, -3 fold increase in expression of c-ras Hp21, and 2 fold increase in the frequency of lactogenic hormone-independent mammary alveolar lesions, MAL. In contrast, exposure of the cultures to eicosapentanoic or stearic acid results in no increase in RT activity, 3-fold decrease in expression of C-ras Hp21, and about 2-fold decrease in MAL frequency. These results suggest that tumor modulating effects of dietary fatty acids may be operative during the initiational and promotional events of viral carcinogenesis, well before the emergence of mammary tumors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
971-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Modulation in the expression of murine mammary tumor virus, ras proto-oncogene, and of alveolar hyperplasia by fatty acids in mouse mammary explant cultures.
pubmed:affiliation
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't