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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1988-11-14
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pubmed:abstractText |
Logistic regression was used to analyze the influence of pretransplant herpesvirus antibodies, in both patients and donors, on the development of acute graft-versus-host disease in 111 consecutive HLA-identical bone marrow recipients. In bivariate analysis, recipient seropositivity for cytomegalovirus (P = 0.01), donor seropositivity for herpes simplex virus (P = 0.02), and low bone marrow cell dosage (P less than 0.05) were associated with a high incidence of grade II-IV acute GVHD. In multivariate analysis the P values were P less than 0.05 for a positive recipient CMV serology and P = 0.07 for a positive donor HSV serology. Positive serology for 1-2 herpes-viruses among recipients or donors both resulted in a 12% incidence of grade II-IV acute GVHD. Positive serology for 3-4 herpesviruses among patients or donors resulted in an incidence of 32% and 38% of acute GVHD, respectively (P less than 0.05). It is concluded that recipient and donor pretransplant herpesvirus immunity can be used to calculate the risk of moderate-to-severe acute GVHD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0041-1337
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
548-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2845612-Acute Disease,
pubmed-meshheading:2845612-Adolescent,
pubmed-meshheading:2845612-Adult,
pubmed-meshheading:2845612-Antibodies, Viral,
pubmed-meshheading:2845612-Bone Marrow Transplantation,
pubmed-meshheading:2845612-Child,
pubmed-meshheading:2845612-Child, Preschool,
pubmed-meshheading:2845612-Female,
pubmed-meshheading:2845612-Graft vs Host Disease,
pubmed-meshheading:2845612-Herpesviridae,
pubmed-meshheading:2845612-Herpesviridae Infections,
pubmed-meshheading:2845612-Humans,
pubmed-meshheading:2845612-Infant,
pubmed-meshheading:2845612-Male,
pubmed-meshheading:2845612-Middle Aged,
pubmed-meshheading:2845612-Preoperative Care,
pubmed-meshheading:2845612-Serologic Tests
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pubmed:year |
1988
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pubmed:articleTitle |
Pretransplant herpesvirus serology and acute graft-versus-host disease.
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pubmed:affiliation |
Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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