| pubmed-article:2845359 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0525039 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:2845359 | lifeskim:mentions | umls-concept:C0205232 | lld:lifeskim |
| pubmed-article:2845359 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:2845359 | pubmed:dateCreated | 1988-11-21 | lld:pubmed |
| pubmed-article:2845359 | pubmed:abstractText | The promoter of mouse DNA polymerase beta gene was analyzed by combining 5'-upstream region of this gene with chloramphenicol acetyltransferase (CAT) gene and by introduction of the recombinant plasmid DNA into mouse NIH/3T3 cells. Serial deletion of the mouse DNA sequence revealed that the promoter function resides within a 33 base pair region from the nucleotide position -48 to -15 with respect to the transcription initiation site, and is highly active without enhancer sequence. The promoter region was separated into two subregions: one (-48 to -35) contains a GC-box and the other contains a 10 base pair palindrome, whose sequence is similar to one of promoter consensus sequences found in a number of promoters including adenovirus promoters. The DNA polymerase beta promoter-directed CAT expression was competitively inhibited by the simultaneous transfection of plasmid DNA containing SV40 early promoter sequence. The viral sequences which are competitive to the GC-box of DNA polymerase beta gene promoter were the GC-boxes of SV40 promoter. Therefore, it is concluded that transcription of mouse DNA polymerase beta gene is regulated by mouse trans-acting factors equivalent to human Sp1 which is known to be trans-acting protein factor acting on SV40 GC-box sequences. | lld:pubmed |
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| pubmed-article:2845359 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2845359 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2845359 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2845359 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2845359 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:2845359 | pubmed:author | pubmed-author:HayashiYY | lld:pubmed |
| pubmed-article:2845359 | pubmed:author | pubmed-author:YamaguchiMM | lld:pubmed |
| pubmed-article:2845359 | pubmed:author | pubmed-author:MatsukageAA | lld:pubmed |
| pubmed-article:2845359 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2845359 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:2845359 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:2845359 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2845359 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2845359 | pubmed:pagination | 8773-87 | lld:pubmed |
| pubmed-article:2845359 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2845359 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2845359 | pubmed:articleTitle | Mouse DNA polymerase beta gene promoter: fine mapping and involvement of Sp1-like mouse transcription factor in its function. | lld:pubmed |
| pubmed-article:2845359 | pubmed:affiliation | Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Nagoya, Japan. | lld:pubmed |
| pubmed-article:2845359 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2845359 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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