Linked Life Data

2844521

Source:http://linkedlifedata.com/resource/pubmed/id/2844521

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-11-15
pubmed:abstractText
Seizure activity is generated and propagated by specific subcortical circuits. The substantia nigra (SN) and the area tempestas (AT) have been identified as two exemplary substrates for the control of experimental seizures. In animal models, GABAergic transmission has been shown to protect against seizures of different origins and methods of induction. Neuroactive peptides and excitatory amino acids may work with GABA in the SN to control the propagation of a wide variety of seizure types. In contrast, inhibition of AT pons selectively protects against seizures associated with limbic circuits. The AT is also a site from which bilaterally synchronous convulsions can be triggered in response to manipulations of cholinergic, GABAergic, and excitatory amino acid receptors. Definition of other pathways of seizure development and the effects of pharmacologic treatments on discrete brain regions await further research efforts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0013-9580
pubmed:author
pubmed:issnType
Print
pubmed:volume
29 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S15-34
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Progression and generalization of seizure discharge: anatomical and neurochemical substrates.
pubmed:affiliation
Department of Pharmacology, Georgetown University Medical Center, Washington, D.C. 20007.
pubmed:publicationType
Journal Article, Review