Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-10-26
pubmed:abstractText
The human bactericidal antibody response to the major outer membrane protein, P2, of nontypeable Haemophilus influenzae was studied. P2 was isolated from two strains of nontypeable H. influenzae and coupled to affinity columns. Pooled normal human serum was subjected to affinity chromatography with the P2 columns and a control column. Reducing the titer of antibody to P2 resulted in reduced bactericidal activity of that serum for the organism. Immunopurified antibody to P2 from human serum was bactericidal for the homologous strain. The extent to which these bactericidal determinants on P2 are conserved among strains was investigated. Immunopurified antibodies to P2 of two epidemiologically unrelated isolates were bactericidal for four of six strains tested. We conclude that P2 is a target for human bactericidal antibody and that some of these determinants that are recognized by human bactericidal antibody are conserved among strains of nontypeable H. influenzae.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-2428838, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-2443581, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-2443611, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-2451640, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-26735, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-2987194, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-3491049, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-3547567, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-3873475, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-3875563, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-3876283, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-4137338, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-4379386, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-4975539, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-4977280, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-5295988, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6343827, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6600447, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6600849, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6601665, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6601684, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6603479, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6605104, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6610409, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6610640, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6966461, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6967963, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6971807, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6972422, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6974204, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6978116, http://linkedlifedata.com/resource/pubmed/commentcorrection/2843467-6979511
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2673-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae.
pubmed:affiliation
Department of Medicine, State University of New York, Buffalo 14215.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.