Linked Life Data

2843193

Source:http://linkedlifedata.com/resource/pubmed/id/2843193

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-10-20
pubmed:abstractText
Cultured astrocytes exposed to ethanol were prelabeled with [3H]inositol and the accumulation of [3H]inositol phosphates was determined following stimulation with norepinephrine (NE). Acute doses of alcohol (25-200 mM) had little effect on phosphoinositide (PI) hydrolysis. However, chronic exposure for 7 days produced significant increases in hydrolysis with ethanol concentrations as low as 50 mM. The onset of alcohol-induced increases occurred within 4 hr of exposure, reaching maximum values by Days 3 to 5. Withdrawal resulted in the return of stimulated PI hydrolysis to pre-alcohol exposure levels after 2 days. The evidence provided suggests that chronic exposure of ethanol alters the alpha-adrenergic receptor characteristics of astrocytes and/or enhances the effector pathway leading to PI hydrolysis at a site distal to the receptor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0741-8329
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Alcohol-induced alterations in phosphoinositide hydrolysis in astrocytes.
pubmed:affiliation
Alcohol Research Center, University of California, Los Angeles 90024-1759.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't