Linked Life Data

2842951

Source:http://linkedlifedata.com/resource/pubmed/id/2842951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-10-7
pubmed:abstractText
Lytic infection with herpes simplex virus causes increased ubiquitin gene transcription. This effect is reproduced in cells expressing the viral immediate early protein ICP4 in the absence of other viral proteins but is not seen at the nonpermissive temperature in cells expressing the temperature-sensitive ICP4 protein of HSV-1 tsK. Studies with probes specific to the three human ubiquitin genes indicate that only the Ubi B gene is sensitive to ICP4-mediated induction whereas the Ubi A and C genes are unaffected. The significance of these effects for the mechanism by which ICP4 transcriptionally activates viral and a few cellular genes is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
258-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The herpes simplex virus type 1 immediate-early protein ICP4 specifically induces increased transcription of the human ubiquitin B gene without affecting the ubiquitin A and C genes.
pubmed:affiliation
Department of Biology, University College London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't