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rdf:type |
|
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lifeskim:mentions |
|
|
pubmed:issue |
9
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|
pubmed:dateCreated |
1988-10-4
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|
pubmed:abstractText |
A novel conformationally restricted 1-cyclopropylquinolone (1) that incorporates structural features of both ofloxacin and ciprofloxacin has been prepared. Compound 1 was found to be a DNA gyrase inhibitor having potency similar to ofloxacin but less than ciprofloxacin. The cellular inhibitory and in vivo antibacterial potencies of 1 were found to be less than those of the two reference agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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|
pubmed:issn |
0022-2623
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1694-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2842501-Animals,
pubmed-meshheading:2842501-Bacteroides,
pubmed-meshheading:2842501-Chemical Phenomena,
pubmed-meshheading:2842501-Chemistry,
pubmed-meshheading:2842501-Ciprofloxacin,
pubmed-meshheading:2842501-Escherichia coli,
pubmed-meshheading:2842501-Mice,
pubmed-meshheading:2842501-Ofloxacin,
pubmed-meshheading:2842501-Oxazines,
pubmed-meshheading:2842501-Pseudomonas aeruginosa,
pubmed-meshheading:2842501-Staphylococcus aureus,
pubmed-meshheading:2842501-Streptococcus,
pubmed-meshheading:2842501-Topoisomerase II Inhibitors
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pubmed:year |
1988
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|
pubmed:articleTitle |
Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative.
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pubmed:affiliation |
Department of Medicinal Chemistry, Sterling-Winthrop Research Institute, Rensselaer, New York 12144.
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pubmed:publicationType |
Journal Article,
Comparative Study
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