Linked Life Data

2840993

Source:http://linkedlifedata.com/resource/pubmed/id/2840993

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-9-12
pubmed:abstractText
Bronchial challenge of ovalbumin-sensitized conscious guinea-pigs induced a triphasic reduction in specific airways conductance (sGaw) with maximal reductions being observed at 2, 17 and 72 h accompanied by infiltration of the airways with neutrophils at 17 h and eosinophils at 17 and 72 h. Nedocromil sodium (10 mg ml-1) inhaled before challenge blocked the 2 and 17 h sGaw response and the neutrophil influx. When inhaled 6 h after challenge, nedocromil inhibited the 17 h sGaw response but not neutrophil influx, suggesting that these are unrelated. The sGaw response and eosinophil accumulation at 72 h was also inhibited by nedocromil given at this time. Our findings correlate with the clinical effects of nedocromil, suggesting the guinea-pig model may be useful for investigating the mechanism of action of anti-asthmatic drugs.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Inhibition by nedocromil sodium of early and late phase bronchoconstriction and airway cellular infiltration provoked by ovalbumin inhalation in conscious sensitized guinea-pigs.
pubmed:affiliation
Immunopharmacology Group, Southampton General Hospital.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't