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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-8-29
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pubmed:abstractText |
An investigation on the conformations of highly receptor-selective opioid peptides was carried out to gain further understanding of the structure-activity relationship of endogenous enkephalins. The preferred conformations of a highly mu-selective [Val4]morphiceptin and a highly delta-selective delta-kephalin have been probed by 1H n.m.r. solvent-, concentration- and temperature-dependences of amide protons to take the folded conformations stabilized by an intramolecular hydrogen bond and the anti-parallely extended dimeric structures respectively. Their possible stereo-conformations were proposed, based on the analyses of the vicinal coupling constants (JHNC alpha H). The conformational difference between the mu- and delta-selective opioid peptides was further ascertained by the c.d. measurements. The c.d. spectra of the mu-selective peptides show negative bands in the range of 210-230 nm, while those of the delta-selective ones show the opposite positive bands. A correlation between c.d. spectra and receptor-selectivity was possible.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-1027428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-1207728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-2862266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-2865874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-3022097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-3458181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-3584096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-38962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-3947345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-3977900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-5799638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6091824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6101980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6247963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6257512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6259732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6263640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6276540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6276710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6301470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6310598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6646225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6721829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-6862767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-7060566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-782788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-9222318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840898-963242
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Conformational characteristics of receptor-selective opioid peptides. 1H n.m.r. and c.d. spectroscopic studies of delta-kephalin and [Val4]morphiceptin.
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pubmed:affiliation |
Osaka University of Pharmaceutical Sciences, Japan.
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pubmed:publicationType |
Journal Article
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