Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-9-1
|
| pubmed:abstractText |
Natural killer (NK) cell activity, lymphokine activated killer (LAK) activity and Epstein-Barr virus specific cytotoxic T lymphocyte (EBV-CTL) activity were examined in 10 children with chronic active EB-virus infection and an adult with persistently positive early antigen-antibody to EB-virus. NK cell activity against erythroleukemia cell line K-562 was significantly (p less than 0.005) lower in the patients (22.3 +/- 8.5%, mean +/- SD) than in normal controls (40.4 +/- 15.9%). Spontaneous cytotoxicity against an EB-virus transformed autologous lymphoblastoid cell line was 15.0 +/- 7.6% in the patients, and was comparable to spontaneous cytotoxicity activity in normal controls (11.7 +/- 4.3%). LAK activity against Raji cells was significantly (p less than 0.02) lower in the patients (14.6 +/- 11.4%) than in normal controls (29.2 +/- 15.9%). EBV-CTL activity against an EB-virus transformed autologous lymphoblastoid cell line was significantly (p less than 0.005) lower in the patients (11.8 +/- 5.5%) than in seropositive normal controls (33.7 +/- 14.7%). No regression of the lymphoblastoid cell line was observed when EBV-CTL activity of the patients was tested by regression assay. It is conceivable that defects in both EB-virus specific and nonspecific killer cell activities play important roles in the pathogenetic abnormalities which allow EB-virus infection to progress to a chronic active state.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0386-300X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
137-42
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2840801-Cell Line, Transformed,
pubmed-meshheading:2840801-Child,
pubmed-meshheading:2840801-Child, Preschool,
pubmed-meshheading:2840801-Chronic Disease,
pubmed-meshheading:2840801-Female,
pubmed-meshheading:2840801-Herpesvirus 4, Human,
pubmed-meshheading:2840801-Humans,
pubmed-meshheading:2840801-Infectious Mononucleosis,
pubmed-meshheading:2840801-Killer Cells, Natural,
pubmed-meshheading:2840801-Lymphokines,
pubmed-meshheading:2840801-Male,
pubmed-meshheading:2840801-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Defective killer cell activity in patients with chronic active Epstein-Barr virus infection.
|
| pubmed:affiliation |
Department of Pediatrics, Kochi Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|