Linked Life Data

2840758

Source:http://linkedlifedata.com/resource/pubmed/id/2840758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-9-1
pubmed:abstractText
Collagenase activity was considered to play an important role in the process of ulcer formation, as one of the aggressive factors. We measured the collagen metabolism using the restraint and water immersion stress ulcer model with time and studied the effects of cimetidine and misoprostol (PGE1 derivative) on the collagen metabolism. The active forms and total collagenases in the gastric mucosal connective tissues were elevated as early as at two hours after loading by restraint and water immersion stress, and a decrease in the amount of collagen (as hydroxyproline) was observed. Increase in the collagenase activity was inhibited in groups to which cimetidine or misoprostol was given before restraint and water immersion. From these results it is believed that an elevation of collagenase activity related directly to tissue destruction might be involved, as well as a decrease in the gastric mucosal blood flow, in the etiology of ulcers due to restraint and water immersion stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0385-0005
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-90
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Collagen and collagenase in ulcer tissue--2. Restraint and water immersion induced gastric lesions and effects of cimetidine and misoprostol.
pubmed:affiliation
Department of Internal Medicine, School of Medicine, Tokai University, Japan.
pubmed:publicationType
Journal Article