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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-9-2
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pubmed:abstractText |
A cAMP binding protein was detected in HL-60 cells using photoaffinity labeling with 8-azido [32P]cAMP. The binding protein was found in a 0.35 M NaCl nuclear protein extract from untreated HL-60 cells and from the HL-60 cells induced to mature with retinoic acid. While the quantity of the cAMP binding protein did not change following the induced differentiation, a second form of the subunit, altered in charge, was present at 3 and 5 days after retinoic acid treatment. The findings indicate that the regulatory subunit of the type II cAMP-dependent protein kinase could be involved in nuclear functions associated with human myeloid cell differentiation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9541
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198-201
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2840443-Azides,
pubmed-meshheading:2840443-Carrier Proteins,
pubmed-meshheading:2840443-Cell Nucleus,
pubmed-meshheading:2840443-Cyclic AMP,
pubmed-meshheading:2840443-Cyclic AMP Receptor Protein,
pubmed-meshheading:2840443-Humans,
pubmed-meshheading:2840443-Leukemia, Myeloid, Acute,
pubmed-meshheading:2840443-Molecular Weight,
pubmed-meshheading:2840443-Protein Kinases,
pubmed-meshheading:2840443-Tretinoin
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pubmed:year |
1988
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pubmed:articleTitle |
A nuclear cAMP binding protein in retinoic acid-treated HL-60 cells.
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pubmed:affiliation |
Department of Pathology, A.B. Hancock, Jr. Memorial Laboratory, Vanderbilt University Cancer Center, Nashville, Tennessee.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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