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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1988-8-31
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pubmed:abstractText |
BN/GRP-like peptides are produced in high concentrations in SCLC cell lines and in low concentrations in beta-lymphoblastoid cell lines. The BN/GRP-like peptides are secreted from SCLC cell line NCI-H345 by stimuli which elevate the intracellular cAMP levels. These stimuli include theophylline, PHI, secretin and VIP. Also, elevated plasma levels of BN/GRP-like peptides are found in patients with extensive SCLC. In these patients the levels of BN/GRP-like peptides can be increased further approximately 5-fold after secretin infusion. Because SCLC cells make and secrete BN/GRP-like peptides, they may function as regulatory peptides in this disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0020-7454
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2840406-Carcinoma, Small Cell,
pubmed-meshheading:2840406-Cell Line,
pubmed-meshheading:2840406-Cyclic AMP,
pubmed-meshheading:2840406-Gastrin-Releasing Peptide,
pubmed-meshheading:2840406-Humans,
pubmed-meshheading:2840406-Lung Neoplasms,
pubmed-meshheading:2840406-Peptides,
pubmed-meshheading:2840406-Receptors, Bombesin,
pubmed-meshheading:2840406-Receptors, Neurotransmitter,
pubmed-meshheading:2840406-Secretin
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pubmed:year |
1988
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pubmed:articleTitle |
BN/GRP-like peptides and receptors in small cell lung cancer.
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pubmed:affiliation |
Biochemistry Department, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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