| pubmed-article:2840331 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2840331 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:2840331 | lifeskim:mentions | umls-concept:C0031705 | lld:lifeskim |
| pubmed-article:2840331 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:2840331 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:2840331 | lifeskim:mentions | umls-concept:C0441587 | lld:lifeskim |
| pubmed-article:2840331 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2840331 | pubmed:dateCreated | 1988-8-26 | lld:pubmed |
| pubmed-article:2840331 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2840331 | pubmed:abstractText | DNA from the singed gene of Drosophila melanogaster was isolated using an inversion between a previously cloned P element at cytological location 17C and the hypermutable allele singed-weak. Five out of nine singed mutants examined have alterations in their DNA maps in this region. The singed locus is a hotspot for mutation during P-M hybrid dysgenesis, and we have analyzed 22 mutations induced by P-M hybrid dysgenesis. All 22 have a P element inserted within a 700-bp region. The precise positions of 10 P element insertions were determined and they define 4 sites within a 100-bp interval. During P-M hybrid dysgenesis, the singed-weak allele is destabilized, producing two classes of phenotypically altered derivatives at high frequency. In singed-weak, two defective P elements are present in a "head-to-head" or inverse tandem arrangement. Excision of one element results in a more extreme singed bristle phenotype while excision of the other leads to a wild-type bristle phenotype. | lld:pubmed |
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| pubmed-article:2840331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2840331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2840331 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2840331 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2840331 | pubmed:month | May | lld:pubmed |
| pubmed-article:2840331 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:2840331 | pubmed:author | pubmed-author:RubinG MGM | lld:pubmed |
| pubmed-article:2840331 | pubmed:author | pubmed-author:O'HareKK | lld:pubmed |
| pubmed-article:2840331 | pubmed:author | pubmed-author:RoihaHH | lld:pubmed |
| pubmed-article:2840331 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2840331 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:2840331 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2840331 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2840331 | pubmed:pagination | 75-83 | lld:pubmed |
| pubmed-article:2840331 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
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| pubmed-article:2840331 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2840331 | pubmed:articleTitle | P element insertions and rearrangements at the singed locus of Drosophila melanogaster. | lld:pubmed |
| pubmed-article:2840331 | pubmed:affiliation | Department of Biochemistry, University of California, Berkeley 94720. | lld:pubmed |
| pubmed-article:2840331 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2840331 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2840331 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:31717 | entrezgene:pubmed | pubmed-article:2840331 | lld:entrezgene |
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