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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-8-26
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pubmed:databankReference |
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pubmed:abstractText |
DNA from the singed gene of Drosophila melanogaster was isolated using an inversion between a previously cloned P element at cytological location 17C and the hypermutable allele singed-weak. Five out of nine singed mutants examined have alterations in their DNA maps in this region. The singed locus is a hotspot for mutation during P-M hybrid dysgenesis, and we have analyzed 22 mutations induced by P-M hybrid dysgenesis. All 22 have a P element inserted within a 700-bp region. The precise positions of 10 P element insertions were determined and they define 4 sites within a 100-bp interval. During P-M hybrid dysgenesis, the singed-weak allele is destabilized, producing two classes of phenotypically altered derivatives at high frequency. In singed-weak, two defective P elements are present in a "head-to-head" or inverse tandem arrangement. Excision of one element results in a more extreme singed bristle phenotype while excision of the other leads to a wild-type bristle phenotype.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-115009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-16052739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-16592430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-17247971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-2855303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-3006025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-3007240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-3016507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-3025586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-3037327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6095450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6276017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6281775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6289435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6295640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6295641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6309410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6320712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6418585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-6777779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2840331-719759
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-83
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
P element insertions and rearrangements at the singed locus of Drosophila melanogaster.
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pubmed:affiliation |
Department of Biochemistry, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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