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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1988-8-19
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pubmed:abstractText |
Spleen cells from BALB/c (H-2d) mice vaccinated with vgB11, a recombinant vaccinia virus which expresses glycoprotein B (gB) of herpes simplex virus type 1 (HSV-1), lysed EMT6 (H-2d) target cells infected with vgB11 or with HSV-1 but did not lyse uninfected EMT6 cells or infected L-929 (H-2k) target cells. Unlabelled target cell competition of lysis showed that only syngeneic cells infected with vgB11 or HSV-1 inhibited lysis of radiolabelled HSV-1-infected targets. These results demonstrate that vgB11 induces H-2-restricted anti-HSV-1 cytotoxic T lymphocytes and that gB is the target antigen.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1317
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69 ( Pt 7)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1731-4
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pubmed:dateRevised |
2008-8-26
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pubmed:meshHeading |
pubmed-meshheading:2839606-Animals,
pubmed-meshheading:2839606-H-2 Antigens,
pubmed-meshheading:2839606-Male,
pubmed-meshheading:2839606-Mice,
pubmed-meshheading:2839606-Mice, Inbred BALB C,
pubmed-meshheading:2839606-Recombinant Fusion Proteins,
pubmed-meshheading:2839606-Recombinant Proteins,
pubmed-meshheading:2839606-Simplexvirus,
pubmed-meshheading:2839606-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2839606-Vaccinia virus,
pubmed-meshheading:2839606-Viral Envelope Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
A recombinant vaccinia virus expressing herpes simplex virus type 1 glycoprotein B induces cytotoxic T lymphocytes in mice.
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pubmed:affiliation |
Department of Molecular Biochemistry, City of Hope National Medical Center, Duarte, California 91010.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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