Linked Life Data

2839095

Source:http://linkedlifedata.com/resource/pubmed/id/2839095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-8-3
pubmed:abstractText
Alveolar macrophages and neutrophils produce superoxide and other free radicals which are important in killing bacteria. The focus of this paper is the inhibition by ethanol of superoxide production and anti-bacterial activity. The signal transduction pathways leading to superoxide production by phagocytic cells will be reviewed. Our hypothesis is that ethanol alters these signal transduction pathways. Stimulation of superoxide production can be initiated by concanavalin A and phorbol esters. Previously, there were reports by us that ethanol, in vitro, inhibits phorbol ester induced superoxide production in rat alveolar macrophages. Our present report states that concanavalin A induced superoxide production was more sensitive to ethanol inhibition than phorbol ester induced superoxide production. The ethanol induced inhibition of alveolar macrophage superoxide production provides a possible mechanism to explain the increased sensitivity of alcoholics to pneumonia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0091-7370
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Ethanol inhibition of signal transduction in superoxide production by rat alveolar macrophages. A proposed mechanism for ethanol related pneumonia.
pubmed:affiliation
Department of Pediatrics, Childrens Hospital, Los Angeles.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review